Luke Keary is set to miss the opening game in this year's State of Origin series after suffering a second concussion in five weeks.
The half-back received a heavy knock to the head during Sydney Roosters' 38-12 loss to Newcastle Knights on Friday, meaning he will require clearance from an independent neurologist before being allowed to play again.
Keary, who previously underwent a concussion assessment during his side's victory over Melbourne Storm on April 19, was seen as a potential starter for New South Wales.
However, Blues coach Brad Fittler is set to be without the 27-year-old for the series opener against Queensland at Suncorp Stadium in Brisbane on June 5.
"Luke's been in great form, he was part of the squad last year and Luke was looking like he was going to break into the team," Blues advisor Greg Alexander told ABC Grandstand on Saturday.
"But I don't think Luke will take part, he won't be fit for game one."
Fittler is due to name his Blues team on Sunday, after the conclusion of round 11 in the NRL season.
Meanwhile, Keary's Sydney team-mate Jared Waerea-Hargreaves has been cited by the match review committee after an incident in the defeat to Newcastle.
The prop received a Grade 1 charge for making dangerous contact with the head or neck area following a tackle on Kalyn Ponga in the second half.
The Roosters have the option of entering an early guilty plea, though such a course of action would mean the player receiving a two-game ban.
|Senegal v Algeria: Focus on collective rather than Mane, Mahrez|
|Ronaldo transfer made everyone happy - Kroos|
|F1 Raceweek: Rivals bid to halt Hamilton and Mercedes - Austrian GP in numbers|
|Rhinos land Lui in Lolohea swap deal with Salford|
|It´s not a done deal - Derby owner hopes Lampard to Chelsea falls through|
|Milestones await Silva in Man City great´s final season|
|England captain Houghton a ´major doubt´ for Norway clash|
|Wimbledon puts Federer ahead of Nadal in controversial seedings move|
|Rivaldo defends Messi and Neymar after Van Gaal criticism|
|´Eighth or ninth is not for me´ - Mourinho cold on Newcastle links|
|Gaari´s 25-yard stunner sends Curacao into quarter-finals|
|Foden can replace me at City, says Silva|
|Rumour Has It: Barca eye United´s Lindelof as De Ligt alternative|
|Padres star Machado homers in Baltimore return|
|Gregg Popovich is the San Antonio Spurs – Coles hails legendary NBA coach|
|´I´m not going to the f****** White House´ – Megan Rapinoe|
|Lukaku to Inter? Nothing is impossible says agent|
|Buffon returning to Juve just an idea for now – agent|
|Yankees set MLB record by homering in 28th successive game|
|Lakers should re-sign D´Angelo Russell – Magic Johnson|
|Knicks will ´do everything´ to attract free agents, says president Mills|
|Zion Williamson receives surprise gift & note from Drew Brees|
|I don´t want to be an embarrassment – Thiago Silva outlines retirement plans|
|Wozniacki, Kerber breeze through at Eastbourne|
|Netherlands and Italy to meet in Women´s World Cup quarters as Asian sides exit|
|Silva confirms plans to leave Manchester City|
|Ghana 2 Benin 2: 10-man Black Stars open AFCON campaign with disappointing draw|
|Djokovic surprised by reported Federer, Nadal Wimbledon seedings|
|Bengals´ first-round pick Williams likely out for season|
|Simon eases through at Eastbourne as Murray heads out|
|Everton complete £22million Gomes signing|
|Starc´s stunning Lord´s show sends ominous message to Australia´s World Cup rivals|
|Nigeria v Guinea: Bonus issue overshadows Super Eagles´ preparations|
|Roy ´hopeful´ of facing India, reveals England captain Morgan|
|WATCH: Goretzka´s back-garden brilliance|
|Cameroon 2 Guinea-Bissau 0: Banana and Bahoken get AFCON holders off to winning start|
|Real Madrid to have women´s team in 2019-20|
|England captain Morgan not panicking after back-to-back losses|
|Messi and Ronaldo will be succeeded by Bernardo Silva – Portugal great Futre|
|Australia clinch semi-final spot as England lose again|
|Man United must sign players before selling Pogba – Neville|
|Struggling Hasan will overcome poor form - Mahmood|
|Uganda v Zimbabwe: Cranes captain Onyango ready for familiar foes|
|Lara ´fine´ after being admitted to Mumbai hospital|
|Roma bring in Petrachi as new sporting director|
|Mbappe could play at 2020 Olympics|
|Sign him up! – Kompany backs Lampard for Chelsea job|
|Tottenham target Ndombele plans to leave Lyon, confirms president|
|New Zealand v Pakistan: Sarfraz´s side out to keep semi-final chances alive|
|I have everything to prove – Kompany ready for new chapter at Anderlecht|
|AFC Champions League Review: Kashima and Guangzhou edge thrilling ties|
|Di Biagio claims he did a ´great job´ despite Italy´s early Euro U21s exit|
|F1 Raceweek: Wolff seeking Austrian redemption for Mercedes|
|England fight back after Finch century|
|It´s my big dream - Mane would swap Champions League crown for AFCON success|
|Lara taken to Mumbai hospital with chest pains|
|Egypt v DR Congo: AFCON hosts ponder Salah experiment with last 16 in sight|
|Lampard to Chelsea: Returning heroes - the hits and misses|
|Smith and Warner booed by England fans at Lord´s|
|Torres looking forward to ´perfect finale´ with Iniesta and Villa|
|Paddy Lowe will not return to Williams|
|Derby grant Lampard permission to speak to Chelsea|
|Jean Lucas signs for Lyon amid Ndombele exit talk|
|Wladimir Klitschko rescued from yacht after fire|
|Stephen Curry 10 years on: The six players drafted before the Warriors star|
|Stephen Curry 10 years on: An NBA trailblazer in numbers|
|US president Trump criticises Rapinoe´s anthem protest|
|Stephen Curry 10 years on: Warriors pick the perfect script - ex-college coach|
|Australia turn to Lyon as England stick with Sri Lanka XI|
|Brawn welcomes Hamilton insight on new F1 rules|