Argentina are the biggest World Cup name in danger of being sent home early from Russia 2018.
After taking a single point from their first two matches in Group D, Lionel Messi and his side need to produce something special against Nigeria to stay in the tournament.
But there are plenty of other teams yet to secure their place in the knockout stage of the World Cup, while a few nations are already assured of their exits.
Here, we wrap up everything you need to know about the permutations for all eight groups heading into the final round of fixtures.
Russia and Uruguay have already confirmed they will be in the last 16, but top spot is still up for grabs when they meet in Samara on Monday. But with Spain potentially finishing behind Portugal in Group B, the advantage may be minimal.
In the other game between Mohamed Salah's Egypt and Saudi Arabia, only pride is at stake. Saudi Arabia have finished bottom of their group at their past three World Cups.
Euro 2016 champions Portugal and Iberian neighbours Spain were strongly tipped to be the two sides to go through from Group B and with one game remaining, that situation looks set to happen.
Spain play already-eliminated Morocco in their last game and they only need a point, while Iran have to upset Cristiano Ronaldo's Portugal to leapfrog them in the table and qualify.
Despite failing to impress in one-goal wins over Australia and Peru, hotly tipped France are guaranteed of a place in the round of 16. Les Bleus play Denmark in their final fixture, with the latter requiring a point to be certain of following them through Group C.
With Peru out after failing to score in either of their defeats, Australia will be hoping for three points that would draw them level with Denmark, should they lose to France.
If teams finish level on points, goal difference will be used to decide the final group placings. Goals scored is the next criteria, followed by the head-to-head record of the tied teams. Should there still be no winner, fair play points will be tallied. And if it is still a tie, FIFA will draw lots.
Argentina's fate is out of their hands, but Nigeria's defeat of Iceland on matchday two was a good result for the two-time winners. Messi's men have to beat the Super Eagles to move onto four points, giving themselves a chance of progressing.
But they could be out anyway if Iceland can beat Group D leaders Croatia, who may feel their last match is a chance to rest players for the knockout rounds. Nigeria captain John Obi Mikel has already warned Croatia to play their strongest side against Iceland.
Should Argentina be knocked out, it will be the first time they fail to make it through the group stage in 16 years.
While Argentina have toiled in Group D, South American rivals Brazil look set to make it through Group E - even though their passage has not been straightforward with two late goals needed to down Costa Rica in their last match.
Tite's men are through if they get at least a point against Serbia in Moscow on Wednesday. After Xherdan Shaqiri's late winner in Switzerland's 2-1 defeat of Serbia, they are in pole position to follow Neymar's side through.
Costa Rica are out, with Switzerland only needing to avoid defeat to guarantee qualification from the group stage for the third time in the last four World Cups.
Toni Kroos' dramatic late winner on Saturday kicked Germany's campaign into gear and they can secure their progression to the last 16 if they match Sweden's result in the final game.
Mexico only need a draw against Sweden to qualify, while the latter will go through should they better Germany's result against South Korea.
South Korea face an uphill challenge, they have to beat the defending world champions and hope Sweden lose, while also improving their goal difference.
Things are very simple for England and Belgium, they are both already through and should there be a winner in Kaliningrad on Thursday, they will top the group.
Were the clash to end as a draw, first place would be decided on the number of cards received due to identical records elsewhere. England currently have one fewer.
Should both sides finish with the same number, lots will be drawn.
Poland are out, but the remaining three teams could still reach the knockout stage.
Draws for Japan (against Poland) and Senegal (against Colombia) will send the top two through, however, Colombia will qualify if they beat their African rivals.
If Colombia win, Japan will need to lose by fewer goals than Senegal to progress.
|Aguero signs City contract extension until 2021|
|Stress from drink-driving charge may have contributed to Lloris injury – Pochettino|
|CBF backs Cruzeiro´s Dede appeal and suggests VAR investigation|
|The big Friday Premier League quiz|
|Red Sox clinch AL East with win over Yankees|
|Brighton star Knockaert reveals battle with depression|
|Bud Light beer fridges open after Browns snap 19-game winless streak|
|Browns end 635-day drought with first win since 2016 after downing Jets|
|Blue Jays overturn 8-2 deficit in improbable ninth-inning comeback|
|Colo Colo 0 Palmeiras 2: Scolari´s men poised for Libertadores SFs|
|Tour Championship would enhance successful year, says Tiger|
|Pogba: Man United getting better after winning run|
|What bothers me is that he has time to even do that – LeBron responds to Trump tweet|
|Cowboys most valuable NFL team for 12th successive year|
|Mkhitaryan aiming for glory with Europa specialist Emery|
|Sarri: Pedro´s injury is not too serious|
|This Week in U.S. Sports: Drama in Minnesota, a Judge returns and tragedy in Iowa|
|Tottenham will overcome rough patch – Lamela|
|Torreira impresses for Arsenal but leaves with knock|
|Gattuso urges Higuain to be less predictable with his movement|
|Steelers´ Brown: ´Obviously I don´t want to be traded´|
|Woods, Fowler share Tour Championship lead|
|LeBron James backs Serena Williams after US Open controversy|
|Thiem into St Petersburg quarters, but retiring Youzhny bows out|
|Wigan clinch home semi-final with win over Huddersfield|
|Can apologises following sexism accusations|
|De Bruyne expects to be back for Manchester derby|
|Celtic 1 Rosenborg 0: Griffiths late show lifts Hoops|
|Woods eagles 18 to make 65 at Tour Championship|
|Arsenal 4 Vorskla 2: Aubameyang at the double in entertaining triumph|
|Dudelange 0 AC Milan 1: Deflected Higuain goal spares Gattuso´s blushes|
|Birthday boy Rashid inspires Afghanistan to Asia Cup win|
|Sarri feeling sorry for ´unlucky´ Morata|
|Ryder Cup pick Garcia shoots 66 at Portugal Masters|
|Ronaldo, Zidane, Cantona and the most infamous red cards|
|Villarreal 2 Rangers 2: Arfield and Lafferty steal point for Gerrard´s men|
|PAOK 0 Chelsea 1: Willian strikes as Morata misfires|
|Rain delays Ostapenko in Seoul, Wang books Guangzhou semi|
|Pochettino backs Kane to end goal drought|
|We figured it out - 76ers´ Markelle Fultz rebuilds jump shot|
|Joshua: Povetkin my second-toughest fight|
|Relaxed Pochettino not pushing panic button|
|Why Manchester City fans must fix their relationship with the Champions League|
|Majestic Giorgi ends Wozniacki´s reign in Tokyo|
|Pochettino unwilling to risk Alli fitness|
|Bigger Champions League tests to come, warns Pogba|
|Eight for 10! - Nadeem spins his way to world-record figures|
|A 4-1 lead cut to 3-2 by VAR, but Quakes have no complaints after Atlanta defeat|
|UEFA opens disciplinary proceedings against Ronaldo|
|Joshua v Povetkin: Recapping AJ´s previous world title defences|
|Players told to ink twice over showing tattoos at Rugby World Cup in Japan|
|Mariano targeting Spain call-up after goalscoring Madrid return|
|Pandya, Axar and Thakur out of Asia Cup|
|England omit Cipriani, Tuilagi and Ashton called up|
|Can reacts to Ronaldo´s red card: We are not women|
|One Year to Go: Five Rugby World Cup debutants set to shine|
|Shy Osaka not comfortable with new-found fame|
|Belgium and World Cup winners France make FIFA rankings history|
|Ronaldo wanted to impress - Bernardeschi sympathises after Juve superstar´s red|
|Van Dijk warns Liverpool: Believe we can win trophies or stay home|
|Menezes complains of anti-Brazilian conspiracy after Dede´s VAR red|
|Diamondbacks rout Cubs to remain in postseason picture|
|Modric embraces Ballon d´Or chants as Di Francesco backs Madrid star for award|
|MLS Review: Martinez helps Atlanta stage comeback amid VAR controversy|
|Kerevi recommits to Wallabies, Reds|
|Lyon to ban fan for life after footage of Nazi salute emerges|
|Milan must respect opponents – Gattuso not underestimating Dudelange|
|Copa Libertadores Review: Zarate leads Boca, River draw|
|Mourinho: Dalot can play at Man United for more than 10 years|
|Johnson hoping to erase East Lake demons|